Headache Treatment – Alternative or Illicit?

Originally posted on brainblogger.com 

by Jennifer Gibson, PharmD | April 21, 2011

“Headache disorders can be painful and debilitating conditions. Ranging from infrequent tension-type headaches to cluster headaches to migraines, headaches affect nearly every individual at one time or another. Pain – particularly of the neck and back – accompany many headaches. Traditional pharmacological treatment begins with acetaminophen (Tylenol), but this is not effective for all headache sufferers. More potent pain-killers are used in a step-wise manner to treat pain associated with headache, and preventive and abortive treatments are available and effective for certain types of headache. The most alarming headache treatment option to emerge is the use of lysergic acid diethylamide (LSD) and psilocybin (a hallucinogen derived from mushrooms).

The acknowledgement that hallucinogenic drugs might have a benefit in headache treatment first appeared in the medical literature in the 1960’s and 1970’s. Of course, the stigma associated with drug use at that time was not what it is today, and the dangers associated with drug use were not as well-defined. Now, more than 50 years after Timothy Leary was expelled from Harvard, arguably for supporting the use of illegal drugs, LSD is returning to the school. A Harvard professor is now self-funding research to prove that hallucinogenic drugs are effective headache treatment.

In 2006, an analysis of people who took LSD and/or psilocybin to treat cluster headaches was published by Harvard researchers. The report included results from interviews with 53 patients who had used the psychedelic agents to self-treat cluster headaches. Remarkably, a majority of patients reported benefits of the drugs, including an end to headaches and an extended remission period. The data is limited owing to a small sample size and recall bias; the study was not controlled or randomized.

The use of treatments other than traditional pharmacological management is increasing, owing to general dissatisfaction with traditional medicine, the risk of side effects of traditional headache treatments, and a desire for patient autonomy in healthcare. However, herbal supplements or massage techniques to treat headaches are a far cry from hallucinogenic drugs. The scientist leading the research into hallucinogens claims that his work has produced a non-hallucinogenic derivative of LSD. He is investigating the effectiveness of the compound and is interested in seeking FDA approval for the agent. So far, no major pharmaceutical companies are interested in joining forces with him.” CLICK THE LINK BELOW TO READ THE ENTIRE ARTICLE>>>>

Headache Treatment – Alternative or Illicit?